International 15q Day: 15th November 2013

Int 15q heading Europe
Organizations that support individuals with Prader-Willi Syndrome, Angelman Syndrome and Dup 15q Syndrome are joining forces to create International 15q Day on November 15th. This initiative has been led by the International Prader-Willi Syndrome Organisation, the Angelman Syndrome Foundation and the Dup5q Alliance with a view to raising awareness about the three syndromes. PWSAI is delighted to support this initiative.

Why November 15th? The genetic complications that cause Angelman, Prader-Willi and Dup15q syndromes all originate from the q11-q13 region of the 15th chromosome, which is written as 15q11-q13, and directly correlates to November 15, 2013 written as a numerical date: 15.11.13—-which only comes once every hundred years.

Same Difference. Angelman, Prader-Willi and Dup15q syndromes are different disorders and each is caused by different genetic variations within the q11-q13 region of the 15th chromosome. However, our three related disorders share overlapping symptoms, and each disorder is commonly misdiagnosed with another disorder due to lack of awareness.

The following graphics illustrate the genetic variations that cause Angelman, Prader-Willi and Dup15q syndromes, and the symptoms that each disorder share.

Symtoms overlap 15q-Diagram

Genetic causes of 15q11-13 disorders